| 克隆類型 ： |
Rabbit Polyclonal Antibody, Phosphospecific Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser94 of human YAP1. |
|
產(chǎn)品描述 ： |
YAP (Yes-associated protein) is a transcription coactivator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis and in organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteosomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. Dysregulation of the Hippo-YAP pathway is frequently observed in human cancers. AMPK directly phosphorylates YAP at Ser94, a residue essential for the interaction with TEAD, thus disrupting the YAP-TEAD interaction. |
| 適用物種 ： |
H, M, R |
|
應(yīng)用范圍 ： |
E, WB |
| 應(yīng)用說明 ： |
YAP1 (Ser94) Antibody recognizes endogenous and transfected levels of YAP1 when phosphorylated at Ser94 (Ser79 in mouse and rat). E: 1:5,000-1:20,000; WB: 1:1,000-1:10,000 |
| 別 名 ： |
Yorkie homolog; 65 kDa Yes-associated protein; YAP65; YAP1; Transcriptional coactivator YAP1; Yes-associated protein 1; Yes associated protein YAP65 homolog |
|
形 態(tài) ： |
Each vial contains 0.1 ml IgG in PBS pH7.4, 1 mg/ml BSA, 50% glycerol, and 0.1% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
產(chǎn)品文獻(xiàn) ： |
Mo J-S. et al. 2015. Nature Cell Biology. 17(3): 500-10. PMID# 25751140. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/yap1-ser94-antibody |
| 標(biāo) 記 物 ： |
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產(chǎn)品說明 ： |
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