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產(chǎn)品貨號Reference:             CAN-FPSA-4400
檢測方法Kit Type:                Sandwich ELISA
規(guī)格Kit Size:                        96-well break-apart microplate
靈敏度Sensitivity:                0.05 ng/mL
檢測樣本Sample Type:         Human serum / 50 μL
檢測范圍Calibrator Range:  0.1–15 ng/mL
檢測時間Total Assay Time:  75 minutes

背景介紹：
前列腺特異性抗原(PSA)是由前列腺上皮細(xì)胞分泌的一種分子量為33 kDa的糖蛋白。在人血清中，前列腺特異性抗原主要與α-1-抗糜蛋白酶結(jié)合，但與其他血清蛋白結(jié)合的程度較小。只有一小部分PSA以游離形式存在(自由PSA)。男性血清PSA的正常值低于4 ng/mL。PSA濃度升高表明前列腺病理改變，包括良性前列腺增生(BPH)和前列腺癌。游離PSA(FPSA)已被研究，試圖幫助區(qū)分BPH和未治療的前列腺癌。這些研究表明，未治療的前列腺癌患者游離PSA/總PSA比值低于BPH患者。
Prostate specific antigen (PSA) i s a 3 3-kDa glycoprotein secreted by epithelial cells of the prostate gland. In human serum, PSA is primarily complexed with α1-antichymotrypsin, and to a lesser extent with other serum proteins. Only a small fraction of PSA is present as the free form (free PSA). The expected normal level of PSA in male serum is lower than 4 ng/mL. A rise in the concentration of PSA indicates prostate pathology, including benign prostatic hyperplasia (BPH) and prostate cancer. Free PSA (fPSA) has been studied in attempts to help distinguish BPH from untreated prostate cancer. These studies have shown that the ratio of free PSA / total PSA is lower in untreated prostate cancer than in patients with BPH.