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Ⅳ型膠原是基底膜的主要成分，可作為觀察基底膜是否存在和檢查其結(jié)構(gòu)的標(biāo)志。除上皮基底層外，抗Ⅳ型膠原染色間充質(zhì)成分。它有助于鑒別軟組織腫瘤，包括神經(jīng)鞘瘤和平滑肌瘤?？耿粜湍z原抗體在分化良好、惡性后常與這些組織發(fā)生反應(yīng)。在研究腫瘤的血管成分、血管外皮細(xì)胞瘤、血管肉瘤和上皮樣血管內(nèi)皮瘤時(shí)，抗Ⅳ型膠原蛋白的應(yīng)用比非特異性的銀網(wǎng)狀染色法產(chǎn)生更可靠的結(jié)果。

Collagen Type IV is a primary component in the basal lamina that is used as a marker to observe the presence of the lamina and examine its structure. In addition to the epithelial basal lamina, Anti-Collagen Type IV stains mesenchymal components. It is useful for identifying soft tissue cancers including schwannomas and leiomyomas. Anti-Collagen Type IV frequently reacts with these tissues after becoming well-differentiated and malignant. The use of Anti-Collagen Type IV produces more reliable results than non-specific silver reticulum stains when investigating the vascular elements of neoplasms, hemangiopericytoma, angiosarcoma and epithelioid hemangioendothelioma.

 

Clone IHC549

Source Mouse Monoclonal

Positive Control Lung,  Muscle

Dilution Range 1:50-1:200

 

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