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前列腺特異性酸性磷酸酶(PSAP)是在前列腺腺上皮中發(fā)現(xiàn)的一種前列腺酶。PSAP水平在前列腺增生和前列腺癌中升高，在轉(zhuǎn)移性前列腺癌中檢測(cè)到的水平最高。中度過(guò)表達(dá)PSAP也是骨病(如Paget病或甲狀旁腺功能亢進(jìn))、血細(xì)胞病(如鐮狀細(xì)胞病)、多發(fā)性骨髓瘤或溶酶體貯積性疾病(如高雪氏病)的特征。PSAP被認(rèn)為比PSA更敏感，但特異性更低，然而，在適當(dāng)?shù)呐R床環(huán)境下，抗PSAP可以作為抗PSA的有益補(bǔ)充。

Prostatic Specific Acid Phosphatase (PSAP) is a prostatic enzyme found in the glandular epithelium of the prostate. PSAP levels are elevated in hyperplastic prostate and prostate carcinoma, with the highest levels being detected in metastasized prostate cancer. Moderate overexpression of PSAP is also characteristic of diseases of the bone (such as Paget’s disease or hyperparathyroidism), diseases of blood cells (such as sickle-cell disease), multiple myeloma, or lysosomal storage diseases (such as Gaucher’s disease). PSAP is considered more sensitive, yet less specific, than PSA, however Anti-PSAP can act as a useful complement to Anti-PSA under suitable clinical contexts.

 

Clone： IHC655

Source： Mouse Monoclonal

Positive Control： Prostate, Prostate Adenocarcinoma

Dilution Range： 1:50-1:200

 

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