英文名稱(chēng) ： 5α-Androstane-3α, 17β diol Glucuronide(3α-Diol G) Kit

檢測(cè)樣本 ： Human Serum

產(chǎn)品說(shuō)明 ：

產(chǎn)品貨號(hào)Reference:             CAN-DG-460
檢測(cè)方法Kit Type:                Competitive ELISA
規(guī)格Kit Size:                        96-well break-apart microplate
靈敏度Sensitivity:                0.1 ng/mL
檢測(cè)樣本Sample Type:         Human serum / 50 μL
檢測(cè)范圍Calibrator Range:  0.25–50 ng/mL
檢測(cè)時(shí)間Total Assay Time:  45 minutes

 

背景介紹：

 
5-α-雄甾烷-3-α，17-β-二醇葡萄糖醛酸是一種C19類(lèi)固醇，簡(jiǎn)稱(chēng)3-α-Diol G，5α-Diol G或簡(jiǎn)寫(xiě)為α-Diol G，它主要是作為睪酮和雙氫睪酮（DHT）的代謝產(chǎn)物而產(chǎn)生的。它主要產(chǎn)生于靶外周組織，如皮膚，尤其是毛囊周?chē)?。大量?-α-DiolG刺激會(huì)導(dǎo)致過(guò)度的毛發(fā)形成，特別是在女性通常毛發(fā)應(yīng)不多的情況下。
近年來(lái)研究特發(fā)性多毛癥婦女的臨床研究人員對(duì)這種類(lèi)固醇的測(cè)量越來(lái)越感興趣。
5α-Androstane-3α, 17β-diol glucuronide is a C19 steroid and is either abbreviated as 3α-Diol G, 5α-Diol G or simply, α-Diol G. It is produced mainly as a metabolite of testosterone and dihydrotestosterone (DHT). It is largely produced in target peripheral tissues such as the skin, especially around hair follicles. The stimulation by large amounts of 3α-Diol G leads to excessive hair formation, notably where hair is not normally present in women.

In recent years the interest in the measurement of this steroid has increased among clinical investigators studying women suffering from idiopathic hirsutism.