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產(chǎn)品貨號(hào)Reference:              CAN-DH-490
檢測(cè)方法Kit Type:                 Competitive ELISA
規(guī)格Kit Size:                         96-well break-apart microplate
靈敏度Sensitivity:                 0.15 ng/mL
檢測(cè)樣本Sample Type:         Human serum / 25 μL
檢測(cè)范圍Calibrator Range:  0.2–40 ng/mL
檢測(cè)時(shí)間Total Assay Time:  75 minutes

背景介紹：

脫氫表雄酮(DHEA)是一種在腎上腺皮質(zhì)和性腺產(chǎn)生的C19類固醇。DHEA是睪酮和雌激素合成的前體。由于含有17-氧基，DHEA的雄激素活性相對(duì)較弱，約為睪酮的10%。然而，在新生兒、青春期兒童和成年婦女中，循環(huán)中的DHEA水平可能比睪酮濃度高出幾倍，而且外周組織可能迅速轉(zhuǎn)化為更有力的雄激素(雄烯二酮和睪酮)和雌激素。此外，DHEA對(duì)性激素結(jié)合球蛋白的親和力較低。這些因素可能增強(qiáng)DHEA的生理活性。
Dehyroepiandrosterone (DHEA) is a C19 steroid produced in the adrenal cortex and to a lesser extent in the gonads. DHEA serves as precursor in testosterone and estrogen synthesis. Due to the presence of a 17-oxo-group, DHEA has relatively weak androgenic activity, which has been estimated at ~10% that of testosterone. However in neonates, peripubertal children and in adult women, circulating DHEA levels may be several fold higher than testosterone concentrations, and rapid peripheral tissue conversion to more potent androgen (androstenedione and testosterone) and estrogen may occur. Moreover, DHEA has relatively low affinity for sex-hormone binding globulin. These factors may enhance the physiologic biopotency of DHEA.