產(chǎn)品說(shuō)明 ：
產(chǎn)品貨號(hào)Reference: CAN-FTE-6080
檢測(cè)方法Kit Type: Competitive LIA
規(guī)格Kit Size: 96-well break-apart microplate
靈敏度Sensitivity: 0.17 pg/mL
檢測(cè)樣本Sample Type: Human serum / 25 μL
校準(zhǔn)范圍Calibrator Range: 0.25–125 pg/mL
檢測(cè)時(shí)間Total Assay Time: 90 minutes
背景介紹：
睪酮是一種C-19類固醇，男性從睪丸和腎上腺皮質(zhì)分泌，女性從腎上腺皮質(zhì)和卵巢分泌。睪酮也是由雄烯二酮的外周組織產(chǎn)生的，這在男性中沒有什么生理意義，但在女性中，大約有一半的循環(huán)睪酮是從這個(gè)來(lái)源產(chǎn)生的。睪酮測(cè)量主要用于男性性腺功能減退和女性高雄激素狀態(tài)的臨床評(píng)估。
睪酮在血液中循環(huán)與三種蛋白質(zhì)結(jié)合：性激素結(jié)合球蛋白(60-80%)、白蛋白和皮質(zhì)醇結(jié)合球蛋白。只有大約1-2%的總循環(huán)睪酮保持不受約束或自由。盡管目前仍在研究中，但大多數(shù)研究人員都接受將游離睪酮測(cè)定作為生物活性成分的一種衡量標(biāo)準(zhǔn)。建議采用游離睪酮測(cè)定，以克服運(yùn)輸?shù)鞍鬃兓瘜?duì)總睪酮濃度的影響。
Testosterone is a C-19 steroid secreted from the testis and the adrenal cortex in men and from the adrenal cortex and ovaries in women. Testosterone is also produced by peripheral tissues from androstenedione, which is of little physiological signi? cance in men, however in women about half of the circulating testosterone is derived from this origin. Testosterone measurements are used mainly for clinical evaluation of hypogonadism in males and hyper-androgenic states in females.
Testosterone circulates in the blood bound to three proteins: sex hormone binding globulin (60–80%), albumin and cortisol binding globulin. Only about 1–2% of the total circulating testosterone remains unbound or free. Even though it is still under investigation, most researchers accept the free testosterone determination as a measure of the biologically active fraction. Free testosterone determinations are recommended to overcome the influences caused by variations in transport proteins on the total testosterone concentration.
注：本產(chǎn)品僅用于科研用途，不能直接用于人體或臨床診斷使用。
