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背景描述Description：

ClusterofDifferentiation57，CD57又稱NK-1，是一種可在自然殺傷細(xì)胞、部分T淋巴細(xì)胞和正常外周血單個核細(xì)胞、髓系細(xì)胞以及多種多肽、脂類和硫酸軟骨素蛋白多糖中檢測到的抗原。CD57是一種神經(jīng)內(nèi)分泌來源的腫瘤標(biāo)志物，包括嗜鉻細(xì)胞瘤、副神經(jīng)節(jié)瘤、類癌和髓母細(xì)胞瘤，以及各種神經(jīng)腫瘤，包括神經(jīng)瘤、神經(jīng)纖維瘤、神經(jīng)鞘瘤和顆粒細(xì)胞瘤。CD57在神經(jīng)節(jié)細(xì)胞瘤和前列腺癌中也有表達(dá)?？笴D57抗體用于鑒別結(jié)節(jié)性淋巴細(xì)胞性霍奇金淋巴瘤與T細(xì)胞/組織細(xì)胞豐富的大B細(xì)胞淋巴瘤、結(jié)節(jié)性硬化型霍奇金病和濾泡性淋巴瘤。

Cluster of differentiation 57 (CD57), also known as NK-1, is an antigen detectable in natural killer cells, some T-lymphocytes and normal peripheral blood mononuclear cells, myeloid cells, and a variety of polypeptides, lipids, and chondroitin sulfate proteoglycans. CD57 is indicated as a marker for tumors of neuroendocrine origin, including pheochromocytomas, paragangliomas, carcinoid tumor, and medulloblastomas, as well as various neural tumors including neuromas, neurofibromas, schwannomas, and granular cell tumors. CD57 is also detectable in ganglioneuroma and prostate carcinoma. Anti-CD57 is used to distinguish nodular lymphocyte-predominant Hodgkin’s lymphoma from T-cell/histiocyte-rich large B-cell lymphoma, nodular sclerosis Hodgkin’s disease, and follicular lymphoma.

Specifications：

Clone                    IHC539

Source                 Mouse Monoclonal

Positive Control Tonsil

Dilution Range 1:50-1:200

參考文獻(xiàn)References：

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