惠民福利99久久久无码国产精品免费_日韩拍中文字幕无码_色五月激情五月综合网五月天_99精品久久毛片_免费看美女被靠到爽的视频_A∨无码小缝喷白浆在线观看_狠狠久久綜合_日韩综合无码性爱视频播放_在线免费黄片_好大好爽视频免费观看网站

MutS同源物2(MSH2)是一種參與錯(cuò)配修復(fù)途徑的蛋白。該蛋白通常與遺傳性非息肉病性結(jié)直腸癌有關(guān)，該基因的突變與散發(fā)性結(jié)直腸癌的發(fā)生有關(guān)。將抗MSH2與抗MSH6、MLH1和PMS2的抗體配對(duì)在IHC面板中時(shí)，可優(yōu)化抗MSH2的使用。報(bào)告顯示，抗MSH2抗體可用于檢測(cè)許多正常和腫瘤組織中的MSH2蛋白。

MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumors that are microsatellite-unstable.

 

Clone IHC410

Source Mouse Monoclonal

Positive Control Colon Mucosa, Colon Carcinoma

Dilution Range 1:50-1:200

 

Pal T, et al. Cancer. 2008; 113:733-42.

Brueckl WM, et al. Anticancer Res. 2003; 23:1773-8.

Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.

Renkonen E, et al. J Clin Oncol. 2003; 21:3629-37.

Hoedema R, et al. Am Surg. 2003; 69:387-92.

Christensen M, et al. Cancer. 2002; 95:2422-30.

Wahlberg SS, et al. Cancer Res. 2002; 62:3485-92.

Lanza G, et al. Mod Pathol. 2002; 15:741-9.

Thibodeau SN, et al. Cancer Res 1996; 56:4836-40.